Submission Details

VLA-UNK-5c5a631c
Molecule(s):
O=C(C1CCOc2ccc(Cl)cc21)N(CCC(O)S(=O)(=O)O)c1cncc2ccccc12

VLA-UNK-5c5a631c-1

O=C(C1CCOc2ccc(Cl)cc21)N(CCC(O)S(=O)(=O)O)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=CCCN(C(=O)C1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

VLA-UNK-5c5a631c-2

O=CCCN(C(=O)C1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=CCC(=O)N(C(=O)C1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

VLA-UNK-5c5a631c-3

O=CCC(=O)N(C(=O)C1CCOc2ccc(Cl)cc21)c1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Covalent binder variation based on previous successful benzopyran-isoquinoline compound MAT-POS-090737b9-1 (racemate of VLA-UCB-50c39ae8-7) and the feline coronavirus inhibitor GC373 and prodrug GC376. These are just 2-3 step syntheses on Manifold.

Inspired By:
Discussion:

Contributor: Vladimiras Oleinikovas - Sun, 24 Jan 2021 22:21:58 +0000