Submission Details

JAK-UCS-5a86e276

Molecule(s):

CC1(C)[C@H]2CN(C(=O)[C@@H](NC(=O)C(F)(F)Cl)S(C)(C)C)[C@H](C(=O)N[C@H](C#N)C[C@@H]3NCNC3=O)[C@H]21

JAK-UCS-5a86e276-1

CC1(C)[C@H]2CN(C(=O)[C@@H](NC(=O)C(F)(F)Cl)S(C)(C)C)[C@H](C(=O)N[C@H](C#N)C[C@@H]3NCNC3=O)[C@H]21

Check Availability on Manifold View

Design Rationale:

Functional group alterations to nirmatrelvir (paxlovid) made by eye and not quantitatively analyzed.

Inspired By:

CC(C)(C)[C@H](NC(=O)C(F)(F)F)C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)N[C@H](C#N)C[C@@H]1CCNC1=O)C2(C)C

MAT-POS-7ed7af85-1

Discussion:

Contributor: Jake Anderson, UC San Diego - Fri, 12 Aug 2022 04:18:54 +0000