Submission Details

CHR-SOS-59746812
Molecule(s):
O=C(CC1(Cc2ccccc2)CCCC1)Nc1cccnc1

CHR-SOS-59746812-1

O=C(CC1(Cc2ccccc2)CCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(CC1(Cc2cccnc2)CCCC1)Nc1cccnc1

CHR-SOS-59746812-2

O=C(CC1(Cc2cccnc2)CCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
Cc1ncc(CC2(CC(=O)Nc3cccnc3)CCCC2)s1

CHR-SOS-59746812-3

Cc1ncc(CC2(CC(=O)Nc3cccnc3)CCCC2)s1

3-aminopyridine-like Check Availability on Manifold View
Cc1ncc(CC2(CC(=O)Nc3cccnc3)CCCCC2)s1

CHR-SOS-59746812-4

Cc1ncc(CC2(CC(=O)Nc3cccnc3)CCCCC2)s1

3-aminopyridine-like Check Availability on Manifold View
O=C(CC1(Cc2ccccc2)CCCCC1)Nc1cccnc1

CHR-SOS-59746812-5

O=C(CC1(Cc2ccccc2)CCCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(CC1(Cc2cccnc2)CCCCC1)Nc1cccnc1

CHR-SOS-59746812-6

O=C(CC1(Cc2cccnc2)CCCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Structure-based design: - Combination of X_0678 and X_0946 with CH2 linker - Combination of X_0678 and pyridine version of X_0946 with CH2 linker - Combination of X_0678 and methyl-thiazole isostere of X_0946 with CH2 linker - Combination of cyclopentyl version of X_0678 and X_0946 with CH2 linker - Combination of X_0678 and pyridine version of X_0946 with CH2 linker - Combination of X_0678 and methyl-thiazole isostere of X_0946 with CH2 linker

Inspired By:
Discussion:

Contributor: Chris de Graaf, Sosei Heptares - Sat, 21 Mar 2020 01:38:06 +0000