Submission Details
Molecule(s):
CNC(=O)OC1CCN(C(=O)N2CCCCC2)CC1
CNC(=O)OC1CCN(C(=O)c2ccccc2)CC1
CNC(=O)OC1CCN(C(=O)c2ccncc2)CC1
CNC(=O)OC1CCN(S(=O)(=O)c2ccccc2)CC1
CNC(=O)OC1CCN(Cc2ccccc2)CC1
Design Rationale:
By eye. Replacement of the inspired fragment, bearing primary chloride, with other possibility of a semi/covalent inhibition of the enzyme. Substitution with a carbamate (like e.g. physostigmine and Acetylcholinesterase inhibitors).
Other Notes:
Simple and easy chemical synthesis, most of building blocks are commercially available