Submission Details

EDJ-MED-54fbebd8
Molecule(s):
CNS(=O)(=O)CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

EDJ-MED-54fbebd8-1

CNS(=O)(=O)CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

3-aminopyridine-like Check Availability on Manifold View
CNC(=O)CCN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

EDJ-MED-54fbebd8-2

CNC(=O)CCN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

3-aminopyridine-like Check Availability on Manifold View
O=C(CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1)NC1CC1

EDJ-MED-54fbebd8-3

O=C(CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1)NC1CC1

3-aminopyridine-like Check Availability on Manifold View
N#CCNC(=O)CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

EDJ-MED-54fbebd8-4

N#CCNC(=O)CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

3-aminopyridine-like Check Availability on Manifold View
CS(=O)(=O)CNC(=O)CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

EDJ-MED-54fbebd8-5

CS(=O)(=O)CNC(=O)CN1Cc2ccccc2C(C(=O)Nc2cncc3ccccc23)C1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Analogues of MAT-POS-4223bc15-23 modulating internal hydrogen bond proposed from x-ray. Avoid over acidifying the pendant NH to prevent zwitterion formation.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Tue, 15 Jun 2021 17:08:45 +0000