Submission Details

EDJ-MED-50fe53e8
Molecule(s):
O=C(Cc1cccc(Cl)c1)Nc1nncc2ccccc12

EDJ-MED-50fe53e8-1

O=C(Cc1cccc(Cl)c1)Nc1nncc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1cnnc2ccccc12

EDJ-MED-50fe53e8-2

O=C(Cc1cccc(Cl)c1)Nc1cnnc2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1ncn2ccccc12

EDJ-MED-50fe53e8-3

O=C(Cc1cccc(Cl)c1)Nc1ncn2ccccc12

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Cc1cccc(Cl)c1)Nc1ncc2ccccn12

EDJ-MED-50fe53e8-4

O=C(Cc1cccc(Cl)c1)Nc1ncc2ccccn12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Improve isoquinoline hydrogen bond strength by alteration of heterocycle. Also substitution of Cl with nitrile to increase potency.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Mon, 20 Jul 2020 22:12:06 +0000