Submission Details

RAL-THA-4a5dabff
Molecule(s):
O=C(Cn1nnc2ccccc21)N(Cc1ccsc1)c1ccccc1

RAL-THA-4a5dabff-1

O=C(Cn1nnc2ccccc21)N(Cc1ccsc1)c1ccccc1

3-aminopyridine-like Check Availability on Manifold View
CN(C)c1ccc(N(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cn1

RAL-THA-4a5dabff-2

CN(C)c1ccc(N(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cn1

3-aminopyridine-like Check Availability on Manifold View
O=C(Cn1nnc2ccccc21)N(Cc1ccsc1)c1cccnc1

RAL-THA-4a5dabff-3

O=C(Cn1nnc2ccccc21)N(Cc1ccsc1)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(Cn1nnc2ccccc21)C(Cc1ccsc1)c1ccccc1

RAL-THA-4a5dabff-4

O=C(Cn1nnc2ccccc21)C(Cc1ccsc1)c1ccccc1

3-aminopyridine-like Check Availability on Manifold View
CN(C)c1ccc(C(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cc1

RAL-THA-4a5dabff-5

CN(C)c1ccc(C(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cc1

3-aminopyridine-like Check Availability on Manifold View
CCC(=O)Nc1ccc(C(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cc1

RAL-THA-4a5dabff-6

CCC(=O)Nc1ccc(C(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cc1

3-aminopyridine-like Check Availability on Manifold View
CCC(=O)Nc1ccc(C(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cn1

RAL-THA-4a5dabff-7

CCC(=O)Nc1ccc(C(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cn1

3-aminopyridine-like Check Availability on Manifold View
CCC(=O)Nc1ccc(N(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cn1

RAL-THA-4a5dabff-8

CCC(=O)Nc1ccc(N(Cc2ccsc2)C(=O)Cn2nnc3ccccc32)cn1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Follow up of benztriazole series, e.g. ALP-POS-c59291d4-2. The objective with this set of compounds to to probe the possibility of replacing the embedded 1,4-dianiline, a somewhat risky structural feature that is often activated to produce reactive metabolites. Although a few of the targets are still aniline derivatives, they are included for SAR purposes to compare with the corresponding aminopyridyls. The thiophene is also such a risky gtoup, but for the purpose of comparative SAR is kept constant here.

Inspired By:
Discussion:

Contributor: Ralph Robinson, thames pharma partners - Wed, 09 Sep 2020 01:02:27 +0000