Submission Details

NAU-LAT-445f63e5
Molecule(s):
O=S(=O)(CCc1ccccc1)Nc1cccnc1

NAU-LAT-445f63e5-1

O=S(=O)(CCc1ccccc1)Nc1cccnc1

O=S(=O)(Cc1ccc(F)cc1)Nc1cccnc1

NAU-LAT-445f63e5-2

O=S(=O)(Cc1ccc(F)cc1)Nc1cccnc1

O=S(=O)(Cc1noc(C2CC2)n1)Nc1cccnc1

NAU-LAT-445f63e5-3

O=S(=O)(Cc1noc(C2CC2)n1)Nc1cccnc1

N#Cc1cccnc1NS(=O)(=O)Cc1ccccc1

NAU-LAT-445f63e5-4

N#Cc1cccnc1NS(=O)(=O)Cc1ccccc1

O=S(=O)(Cc1ccccc1)Nc1cnccc1N1CCCC1

NAU-LAT-445f63e5-5

O=S(=O)(Cc1ccccc1)Nc1cnccc1N1CCCC1

O=C(Nc1cccnc1)NC1(Cc2ccccc2)CCOCC1

NAU-LAT-445f63e5-6

O=C(Nc1cccnc1)NC1(Cc2ccccc2)CCOCC1

3-aminopyridine-like Made Check Availability on Manifold View
O=S(=O)(NC1(Cc2ccccc2)CCOCC1)c1cccnc1

NAU-LAT-445f63e5-7

O=S(=O)(NC1(Cc2ccccc2)CCOCC1)c1cccnc1

Design Rationale:

Bioisosteric replacements/growing on early successful fragments TRY-UNI-714a760b-6 and JAG-UCB-cedd89ab-8.

Inspired By:
Discussion:

Contributor: Nauris Narvaiss, Latvian Institute of Organic Synthesis - Sun, 17 May 2020 20:31:30 +0000