Submission Details
Molecule(s):
Nc1ccc(C2CCN(C(=O)CCl)CO2)cc1
NCc1ccc(C2CCN(C(=O)CCl)CO2)cc1
O=C(CCl)N1CCC(c2ccc(O)cc2)OC1
O=C(CCl)N1CCC(c2ccc(CO)cc2)OC1
O=C(CCl)N1CCC(c2ccc(S)cc2)OC1
O=C(CCl)N1CCC(c2ccc(CS)cc2)OC1
CC(=O)Nc1ccc(C2CCN(C(=O)CCl)CO2)cc1
CC(=O)NCc1ccc(C2CCN(C(=O)CCl)CO2)cc1
CC(=O)Oc1ccc(C2CCN(C(=O)CCl)CO2)cc1
CC(=O)OCc1ccc(C2CCN(C(=O)CCl)CO2)cc1
CC(=O)Sc1ccc(C2CCN(C(=O)CCl)CO2)cc1
CC(=O)SCc1ccc(C2CCN(C(=O)CCl)CO2)cc1
Design Rationale:
Elaborating fragment X_0759 to interact with R188 and M165