Submission Details

EDJ-MED-43f8f7d6
Molecule(s):
CNC(=O)C(C)(C)N1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

EDJ-MED-43f8f7d6-1
Duplicate of:
EDJ-MED-12c4873b-4

CNC(=O)C(C)(C)N1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

Duplicate Ugi Assayed Check Availability on Manifold View
CNC(=O)C1(N2CC(C(=O)Nc3cncc4ccccc34)c3cc(Cl)ccc3C2=O)CC1

EDJ-MED-43f8f7d6-2
Duplicate of:
EDJ-MED-12c4873b-2

CNC(=O)C1(N2CC(C(=O)Nc3cncc4ccccc34)c3cc(Cl)ccc3C2=O)CC1

Duplicate Ugi Assayed Check Availability on Manifold View
CC(C)NC(=O)CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

EDJ-MED-43f8f7d6-3
Duplicate of:
RAL-THA-a9c31980-3

CC(C)NC(=O)CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

Duplicate Ugi Assayed Check Availability on Manifold View
O=C(CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O)NC1CC1

EDJ-MED-43f8f7d6-4

O=C(CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O)NC1CC1

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

EDJ-MED-43f8f7d6-5
Duplicate of:
ALP-POS-e266d783-1

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

Duplicate Ugi Assayed Check Availability on Manifold View
O=C(CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O)NC1COC1

EDJ-MED-43f8f7d6-6

O=C(CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O)NC1COC1

O=C(Nc1cncc2ccccc12)C1CN(C2CCNC2=O)C(=O)c2ccc(Cl)cc21

EDJ-MED-43f8f7d6-7
Duplicate of:
EDJ-MED-12c4873b-6

O=C(Nc1cncc2ccccc12)C1CN(C2CCNC2=O)C(=O)c2ccc(Cl)cc21

Duplicate Ugi Assayed Check Availability on Manifold View
O=C1CC(N2CC(C(=O)Nc3cncc4ccccc34)c3cc(Cl)ccc3C2=O)CN1

EDJ-MED-43f8f7d6-8
Duplicate of:
EDJ-MED-12c4873b-8

O=C1CC(N2CC(C(=O)Nc3cncc4ccccc34)c3cc(Cl)ccc3C2=O)CN1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

EDJ-MED-015fb6b4-2 small lipophilic additions to improve permeability

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Fri, 27 Aug 2021 13:49:24 +0000