Submission Details

JON-CHE-41f76505
Molecule(s):
NC(=O)c1nc(F)cn(CC(=O)N2CCC(C(=O)N3CCCCC3)CC2)c1=O

JON-CHE-41f76505-1

NC(=O)c1nc(F)cn(CC(=O)N2CCC(C(=O)N3CCCCC3)CC2)c1=O

NC(=O)c1nc(F)cnc1OCC(=O)N1CCC(C(=O)N2CCCCC2)CC1

JON-CHE-41f76505-2

NC(=O)c1nc(F)cnc1OCC(=O)N1CCC(C(=O)N2CCCCC2)CC1

Design Rationale:

In a small trial, Favipiravir had a more potent antiviral action on SARS-CoV-2 than lopinavir/ritonavir. Attach Favipiravir to any of the alpha-chloroacetamides fragments. Make the O and N alkylated products.

Inspired By:
Discussion:

Contributor: Jonathan Ahmet, Chemist - Mon, 23 Mar 2020 15:22:37 +0000