Submission Details

Molecule(s):
COCc1csc(CNC(=O)c2ncc(Cl)cc2Cl)c1

JAR-KUA-41bd5a3d-1

COCc1csc(CNC(=O)c2ncc(Cl)cc2Cl)c1

NS(=O)(=O)c1cc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)co1

JAR-KUA-41bd5a3d-2

NS(=O)(=O)c1cc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)co1

Cc1nc(C)c(S(=O)(=O)NCC2CCCC3CC23)s1

JAR-KUA-41bd5a3d-3

Cc1nc(C)c(S(=O)(=O)NCC2CCCC3CC23)s1

Cc1nc(N2CCN(S(=O)(=O)c3ccccc3)CC2)sc1S(N)(=O)=O

JAR-KUA-41bd5a3d-4

Cc1nc(N2CCN(S(=O)(=O)c3ccccc3)CC2)sc1S(N)(=O)=O

Cc1nnc(N2CCN(C(C)c3cccc(Cl)c3)CC2)nc1C

JAR-KUA-41bd5a3d-5

Cc1nnc(N2CCN(C(C)c3cccc(Cl)c3)CC2)nc1C

Cc1csc2ncc(C(=O)N3C4CCC3c3ccccc34)c(=O)n12

JAR-KUA-41bd5a3d-6

Cc1csc2ncc(C(=O)N3C4CCC3c3ccccc34)c(=O)n12

CCS(=O)(=O)c1c(Cl)cccc1CNC(c1cccc(F)c1)C1CC1

JAR-KUA-41bd5a3d-7

CCS(=O)(=O)c1c(Cl)cccc1CNC(c1cccc(F)c1)C1CC1

COCc1csc(-c2nnc(-c3sc(-c4ccccc4)nc3C)o2)c1

JAR-KUA-41bd5a3d-8

COCc1csc(-c2nnc(-c3sc(-c4ccccc4)nc3C)o2)c1

Cc1ccc(S(=O)(=O)NCC(=O)N2CCC(NS(N)(=O)=O)CC2)cc1

JAR-KUA-41bd5a3d-9

Cc1ccc(S(=O)(=O)NCC(=O)N2CCC(NS(N)(=O)=O)CC2)cc1

CCS(=O)(=O)c1cc(Cl)cc(CNS(=O)(=O)c2cccs2)c1

JAR-KUA-41bd5a3d-10

CCS(=O)(=O)c1cc(Cl)cc(CNS(=O)(=O)c2cccs2)c1

Cc1ccc(S(=O)(=O)NCCNC(=O)N2CCN(S(=O)(=O)N3CCCC3)CC2)cc1

JAR-KUA-41bd5a3d-11

Cc1ccc(S(=O)(=O)NCCNC(=O)N2CCN(S(=O)(=O)N3CCCC3)CC2)cc1

COCc1ccccc1CNS(=O)(=O)c1c(C)sc(C)c1C

JAR-KUA-41bd5a3d-12

COCc1ccccc1CNS(=O)(=O)c1c(C)sc(C)c1C

CN(C)S(=O)(=O)N1CCN(C(=O)C2Nc3ccccc3S(=O)(=O)N2)CC1

JAR-KUA-41bd5a3d-13

CN(C)S(=O)(=O)N1CCN(C(=O)C2Nc3ccccc3S(=O)(=O)N2)CC1

CCS(=O)(=O)c1ccc(CNS(=O)(=O)c2cnc(-c3ccccc3)s2)s1

JAR-KUA-41bd5a3d-14

CCS(=O)(=O)c1ccc(CNS(=O)(=O)c2cnc(-c3ccccc3)s2)s1

Cc1nc2scc(C)n2c1CN1CCN(Cc2ccsc2)CC1

JAR-KUA-41bd5a3d-15

Cc1nc2scc(C)n2c1CN1CCN(Cc2ccsc2)CC1

NS(=O)(=O)NCCNS(=O)(=O)c1ccccc1[N+](=O)[O-]

JAR-KUA-41bd5a3d-16

NS(=O)(=O)NCCNS(=O)(=O)c1ccccc1[N+](=O)[O-]

COc1cc(OC)cc(-c2nc(-c3c(C)nc4sccn34)no2)c1

JAR-KUA-41bd5a3d-17

COc1cc(OC)cc(-c2nc(-c3c(C)nc4sccn34)no2)c1

NS(=O)(=O)C1Cc2ccccc2N(CCNS(=O)(=O)c2ccccc2)C1

JAR-KUA-41bd5a3d-18

NS(=O)(=O)C1Cc2ccccc2N(CCNS(=O)(=O)c2ccccc2)C1

CCN(CC)S(=O)(=O)c1ccc(S(=O)(=O)N2CCN(S(N)(=O)=O)CC2)cc1

JAR-KUA-41bd5a3d-19

CCN(CC)S(=O)(=O)c1ccc(S(=O)(=O)N2CCN(S(N)(=O)=O)CC2)cc1


Design Rationale:

Molecules submitted by Kuano for testing

Discussion: