Submission Details
Molecule(s):
O=C(CC(=O)N1CCOCC1)NC1CCCCC1
O=C(CC(=O)N1CCOCC1)Nc1ccccc1
O=C(CCl)CNC(=O)CC(=O)NC1CCCCC1
O=C(CCl)CNC(=O)CC(=O)Nc1ccccc1
O=C(CCl)CNC(=O)CC(=O)NCc1ccccc1
O=C(CC(=O)N1CCOCC1)NCc1ccccc1
O=C(CC(=O)Nc1ccncc1)Nc1ccccc1
Design Rationale:
Malonamides could be used as potential scaffold, due to ther ability to act as a valid peptidomimetic, as it can simulate secondary structure of the natural substrate. Both chloromethyl fragment (covalent interaction) and morpholine fragment (non covalent interaction) are presented as alternative.
Other Notes:
Easy synthesis, for example starting from the opening of Meldrum's acid.