Submission Details

PAU-WEI-3e86dfd8
Molecule(s):
O=C(CCl)N1CCN(C(c2ccc(Br)s2)c2cc(Cl)cc3ccccc23)CC1

PAU-WEI-3e86dfd8-1

O=C(CCl)N1CCN(C(c2ccc(Br)s2)c2cc(Cl)cc3ccccc23)CC1

piperazine-chloroacetamide Check Availability on Manifold View
O=C(CCl)N1CCN(C(c2cccc(Cl)c2)c2ccc(Br)s2)CC1

PAU-WEI-3e86dfd8-2

O=C(CCl)N1CCN(C(c2cccc(Cl)c2)c2ccc(Br)s2)CC1

piperazine-chloroacetamide Check Availability on Manifold View
Design Rationale:

x0770 + x1385 and x0770 + x0830 overlap by eye. Added Cl to Nph substituent in analogy.

Other Notes:

Synthesis from ketone by reductive amination. New stereocenter.

Inspired By:
Discussion:

Contributor: Paul Gehrtz, Weizmann Institute of Science - Mon, 30 Mar 2020 13:20:21 +0000