Submission Details

MAT-POS-37ffad05

Molecule(s):

CNC(=O)CN1CC(C(=O)Nc2cncc3ccc(N(C)S(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

MAT-POS-37ffad05-1

CNC(=O)CN1CC(C(=O)Nc2cncc3ccc(N(C)S(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

Ugi Check Availability on Manifold View

Design Rationale:

Idea from Jag Heer to introduce tertiary sulfonamide on isoquinoline to reduce number of hydrogen bond donors.

Inspired By:

CNC(=O)CN1CC(C(=O)Nc2cncc3ccc(NS(C)(=O)=O)cc23)c2cc(Cl)ccc2C1=O

MAT-POS-2e8b2191-11

Discussion:

Contributor: Matt Robinson, PostEra - Thu, 09 Sep 2021 13:14:16 +0000