Submission Details

EDJ-MED-37aac4bd
Molecule(s):
COC1(C(=O)Nc2cncc3ccccc23)CCOc2cc(Cl)c(Cl)cc21

EDJ-MED-37aac4bd-1
Duplicate of:
EDJ-MED-d08626de-5

COC1(C(=O)Nc2cncc3ccccc23)CCOc2cc(Cl)c(Cl)cc21

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
COCC1(C(=O)Nc2cncc3ccccc23)CCOc2cc(Cl)c(Cl)cc21

EDJ-MED-37aac4bd-2

COCC1(C(=O)Nc2cncc3ccccc23)CCOc2cc(Cl)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
COCC1(C(=O)Nc2cncc3ccccc23)CCOc2c(F)cc(F)cc21

EDJ-MED-37aac4bd-3

COCC1(C(=O)Nc2cncc3ccccc23)CCOc2c(F)cc(F)cc21

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCOc2c(F)cc(F)cc21

EDJ-MED-37aac4bd-4

COC1(C(=O)Nc2cncc3ccccc23)CCOc2c(F)cc(F)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CCOc2ncc(Cl)cc21

EDJ-MED-37aac4bd-5
Duplicate of:
ALP-POS-fe871b40-7

COC1(C(=O)Nc2cncc3ccccc23)CCOc2ncc(Cl)cc21

Duplicate 3-aminopyridine-like Check Availability on Manifold View
COCC1(C(=O)Nc2cncc3ccccc23)CCOc2ncc(Cl)cc21

EDJ-MED-37aac4bd-6

COCC1(C(=O)Nc2cncc3ccccc23)CCOc2ncc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Combination of best S2 SAR - further additions constraining on logP

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Thu, 28 Jan 2021 13:34:20 +0000