Submission Details

JOO-IND-3132366c

Molecule(s):

O=C(CCl)N1CCN([C@@H](c2cccc3ccccc23)N2CCCOCC2)CC1

JOO-IND-3132366c-1

O=C(CCl)N1CCN([C@@H](c2cccc3ccccc23)N2CCCOCC2)CC1

piperazine-chloroacetamide Check Availability on Manifold View

Design Rationale:

Overlay of 0830 and 1077 with covalent warhead. This addresses all vectors inside the protease pocket.

Inspired By:

N#Cc1ccc(N2CCCOCC2)cn1

AAR-POS-d2a4d1df-19

O=C(CCl)N1CCN(Cc2cccc3ccccc23)CC1

MED-COV-4280ac29-31

Discussion:

Contributor: Joost Uitdehaag, industry - Sun, 29 Mar 2020 13:36:01 +0000