Submission Details
Molecule(s):
O=C1Nc2cc(N3CCCC3)ccc2C1=O
Cc1cccc(COC(=O)c2cccc3c2NC(=O)C3=O)c1
O=C1C(=O)N(CCCOc2ccc(Cl)cc2)c2ccccc21
COc1ccccc1OCCN1C(=O)C(=O)c2cc(Br)cc(C)c21
Cc1ccc(OCCN2C(=O)C(=O)c3cccc(Cl)c32)cc1
CCOc1ccccc1CN1C(=O)C(=O)c2cc(Br)ccc21
COc1ccc(CN2C(=O)C(=O)c3cc(Br)cc(C)c32)cc1OC
Cc1cccc(NC(=O)CN2C(=O)C(=O)c3ccccc32)c1
CCc1cccc(CC)c1NC(=O)CN1C(=O)C(=O)c2cc(OC)ccc21
N#Cc1ccc(CN2C(=O)C(=O)c3cccc(Br)c32)c(F)c1
N#Cc1cccc(CN2C(=O)C(=O)c3cccc(Br)c32)c1
CC(C)(C)NC(=O)CN1C(=O)C(=O)c2cccc(Br)c21
O=C1Nc2ccc(OCCF)cc2C1=O
COc1ccc2c(c1F)C(=O)C(=O)N2
COC(=O)c1cc(Br)cc2c1NC(=O)C2=O
N#CCCCOC(=O)c1cccc2c1NC(=O)C2=O
Cc1cccc(C)c1NC(=O)CN1C(=O)C(=O)c2ccccc21
O=C1C(=O)N(Cc2ncon2)c2ccc(Br)cc21
Design Rationale:
These compounds have been chosen to further explore the SAR around our previous submission: LOR-NEU-c8f11034. These have been chosen with an eye to reducing the lipophilicity and altering the electronics of the isatin scaffold.
Other Notes:
Z444349834=NEU-0006847=AA-001 Z358393210=NEU-0006848=AA-001 Z111715598=NEU-0006849=AA-001 Z111479636=NEU-0006850=AA-001 Z1763358916=NEU-0006851=AA-001 Z1776036453=NEU-0006852=AA-001 Z111479666=NEU-0006853=AA-001 Z27790585=NEU-0006854=AA-001 Z85305142=NEU-0006855=AA-001 Z229622108=NEU-0006856=AA-001 Z229622170=NEU-0006857=AA-001 Z229619010=NEU-0006858=AA-001 Z3025441400=NEU-0006859=AA-001 Z1551924411=NEU-0006860=AA-001 Z2733715421=NEU-0006861=AA-001 Z358392728=NEU-0006862=AA-001 Z27072616=NEU-0006863=AA-001 Z992717312=NEU-0006864=AA-001 These compounds are commercially available from Enamine and have been ordered for testing.