Submission Details
Molecule(s):
N#Cc1cncc(Nc2c(Nc3cccnc3)c(=O)c2=O)c1
N#C/N=C(/Nc1cccnc1)Nc1cncc(C#N)c1
CCNc1ncc(C#N)cc1CN1CCC(O)CC1
CCNc1ncc(C#N)cc1CNc1ccno1
CCNc1ncc(C#N)cc1CNc1cc(O)no1
Design Rationale:
Combinations of x195, 434, 305 387 which are in similar positions to try and expand into two pocket. Replacement of urea or sulphonamide with bioisosteres. Some look pretty heteroatom heaving but pyridine could be replaced by benzene.