Submission Details

Molecule(s):
O=c1c(Nc2cccc(Cl)c2)c(Nc2cncc3ccccc23)c1=O

DAR-DIA-2964957d-1

O=c1c(Nc2cccc(Cl)c2)c(Nc2cncc3ccccc23)c1=O

Cc1ccncc1Nc1c(Nc2cccc(Cl)c2)c(=O)c1=O

DAR-DIA-2964957d-2

Cc1ccncc1Nc1c(Nc2cccc(Cl)c2)c(=O)c1=O

O=c1c(Nc2cccc(Cl)c2)c(Nc2n[nH]c3ccccc23)c1=O

DAR-DIA-2964957d-3

O=c1c(Nc2cccc(Cl)c2)c(Nc2n[nH]c3ccccc23)c1=O

O=c1c(Oc2cccc(Cl)c2)c(On2nnc3ccccc32)c1=O

DAR-DIA-2964957d-4

O=c1c(Oc2cccc(Cl)c2)c(On2nnc3ccccc32)c1=O

O=c1c(Nc2cccc(Cl)c2)c(-n2nnc3ccccc32)c1=O

DAR-DIA-2964957d-5

O=c1c(Nc2cccc(Cl)c2)c(-n2nnc3ccccc32)c1=O

O=c1c(NCc2cccc(Cl)c2)c(-n2nnc3ccccc32)c1=O

DAR-DIA-2964957d-6

O=c1c(NCc2cccc(Cl)c2)c(-n2nnc3ccccc32)c1=O

O=c1c(Nc2cccc(Cl)c2)c(Nn2nnc3ccccc32)c1=O

DAR-DIA-2964957d-7

O=c1c(Nc2cccc(Cl)c2)c(Nn2nnc3ccccc32)c1=O

Cc1ccncc1N(C)c1c(Nc2cccc(Cl)c2)c(=O)c1=O

DAR-DIA-2964957d-8

Cc1ccncc1N(C)c1c(Nc2cccc(Cl)c2)c(=O)c1=O

CN(c1cccc(Cl)c1)c1c(Nc2cncc3ccccc23)c(=O)c1=O

DAR-DIA-2964957d-9

CN(c1cccc(Cl)c1)c1c(Nc2cncc3ccccc23)c(=O)c1=O


Design Rationale:

Squaramide as bioisoteric replacement for urea in aminopyridine/isoquinoline/benzotriazole series.

Inspired By:
Discussion: