Submission Details

MAT-UNK-28cf4d29
Molecule(s):
CNC(=O)CN1Cc2ccc(Cl)cc2C(C)(C(=O)Nc2cncc3ccccc23)C1

MAT-UNK-28cf4d29-1
Duplicate of:
MAT-POS-89bd6af1-3

CNC(=O)CN1Cc2ccc(Cl)cc2C(C)(C(=O)Nc2cncc3ccccc23)C1

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
Design Rationale:

Addition of an alpha-methyl group to MAT-POS-4223bc15-23 can reduce any potential amidolysis of the amide bond. Additionally, addition of a methyl-group may increase the population of a bioactive conformation. From an inspection (by eye) of the x-ray structure of MAT-POS-4223bc15-23, it looks like there may be space for a small methyl substituent?

Inspired By:
Discussion:

Contributor: Matthew Duncton - Tue, 14 Sep 2021 15:18:03 +0000