Submission Details
Molecule(s):
CC(=O)N1CCN(CN2CCCOCC2)CC1
O=C(CF)N1CCN(CN2CCCOCC2)CC1
C=CC(=O)N1CCN(CN2CCCOCC2)CC1
O=C(CCl)N1CCN(CN2CCCOCC2)CC1
CC(=O)N1CCN(CN2CCCOCC2)C(C)C1
CC(=O)N1CCN(CN2CCCOCC2)CC1C
CC1CN(C(=O)CF)CCN1CN1CCCOCC1
CC1CN(C(=O)CCl)CCN1CN1CCCOCC1
CC1CN(CN2CCCOCC2)CCN1C(=O)CF
C=CC(=O)N1CCN(CN2CCCOCC2)C(C)C1
C=CC(=O)N1CCN(CN2CCCOCC2)CC1C
N#CN1CCN(CN2CCCOCC2)CC1
CC1CN(C#N)CCN1CN1CCCOCC1
CC1CN(CN2CCCOCC2)CCN1C#N
N#CN1CCN(C2(N3CCCOCC3)CC2)CC1
N#CN1CCN(C(F)(F)N2CCCOCC2)CC1
N#CN1CCN(C(=O)N2CCCOCC2)CC1
N#CN1CCN(C2(N3CCCOCC3)CCO2)CC1
CC(=O)N1CCN(C(=O)N2CCCOCC2)CC1
CC(=O)N1CCN(C(F)(F)N2CCCOCC2)CC1
N#CN1CCN(CN2CCOCCS2(=O)=O)CC1
N#CN1CCN(C(F)N2CCCOCC2)CC1
O=C(CCl)N1CCN(Cc2ccc(Br)s2)CC1
O=C(CF)N1CCN(Cc2ccc(Br)s2)CC1
O=C(CCl)N1CCN(C(=O)c2ccc(Br)s2)CC1
C=CC(=O)N1CCN(C(=O)c2ccc(Br)s2)CC1
N#CN1CCN(Cc2ccc(Br)s2)CC1
CC1CN(C(=O)CCl)CCN1Cc1ccc(Br)s1
CC1CN(Cc2ccc(Br)s2)CCN1C(=O)CCl
O=C(CCl)N1CCN(C(F)(F)c2ccc(Br)s2)CC1
CC(=O)N1CCN(C(F)(F)c2ccc(Br)s2)CC1
O=C(CCl)N1CCN(C2(c3ccc(Br)s3)CC2)CC1
O=C(CCl)N1CCN(C2(c3ccc(Br)s3)CCO2)CC1
C=CC(=O)N1CCN(C2(c3ccc(Br)s3)CCO2)CC1
CC1CN(C(=O)CCl)CCN1C(F)(F)c1ccc(Br)s1
N#CN1CCN(C(F)(F)c2ccc(Br)s2)CC1
N#CN1CCN(C2(c3ccc(Br)s3)CC2)CC1
COCc1cc(CN2CCN(C(=O)CCl)CC2)sc1Br
COCCc1cc(Br)sc1CN1CCN(C(=O)CCl)CC1
COCc1cc(C2(N3CCN(C#N)CC3)CC2)sc1Br
COCCc1cc(Br)sc1C1(N2CCN(C#N)CC2)CC1
Design Rationale:
Addressing excellent overlay of 1385 (cov) and 1077 frags. Added solubility enable by addition of ethers All by eye, inclusion of the thiophene moiety,