Submission Details

Molecule(s):
Cn1cc(NC(=O)NCCc2ccc(Cl)cc2)c2ccccc2c1=O

MAT-POS-2492181e-1

Cn1cc(NC(=O)NCCc2ccc(Cl)cc2)c2ccccc2c1=O

Cn1cc(NC(=O)NCCN2CCCC2)c2ccccc2c1=O

MAT-POS-2492181e-2

Cn1cc(NC(=O)NCCN2CCCC2)c2ccccc2c1=O

CCCN(CCC)CCNC(=O)Nc1cn(C)c(=O)c2ccccc12

MAT-POS-2492181e-3

CCCN(CCC)CCNC(=O)Nc1cn(C)c(=O)c2ccccc12

CC(C)Cn1cc(NC(=O)NCCc2ccc(Cl)cc2)c2ccccc2c1=O

MAT-POS-2492181e-4

CC(C)Cn1cc(NC(=O)NCCc2ccc(Cl)cc2)c2ccccc2c1=O

Cn1cc(NC(=O)NCCc2ccsc2)c2ccccc2c1=O

MAT-POS-2492181e-5

Cn1cc(NC(=O)NCCc2ccsc2)c2ccccc2c1=O

CC(C)Cn1cc(NC(=O)NCCCN2CCC(C)CC2)c2ccccc2c1=O

MAT-POS-2492181e-6

CC(C)Cn1cc(NC(=O)NCCCN2CCC(C)CC2)c2ccccc2c1=O

CC(C)Cn1cc(NC(=O)NCCN2CCC(C)CC2)c2ccccc2c1=O

MAT-POS-2492181e-7

CC(C)Cn1cc(NC(=O)NCCN2CCC(C)CC2)c2ccccc2c1=O

CC(C)Cn1cc(NC(=O)Nc2ccc(N3CCC(C)CC3)cc2)c2ccccc2c1=O

MAT-POS-2492181e-8

CC(C)Cn1cc(NC(=O)Nc2ccc(N3CCC(C)CC3)cc2)c2ccccc2c1=O

3-aminopyridine-like Check Availability on Manifold View
CC(C)Cn1cc(NC(=O)Nc2ccc(CN3CCC(C)CC3)cc2)c2ccccc2c1=O

MAT-POS-2492181e-9

CC(C)Cn1cc(NC(=O)Nc2ccc(CN3CCC(C)CC3)cc2)c2ccccc2c1=O

3-aminopyridine-like Check Availability on Manifold View
CC(C)Cn1cc(NC(=O)NCCCN2CCCCC2C)c2ccccc2c1=O

MAT-POS-2492181e-10

CC(C)Cn1cc(NC(=O)NCCCN2CCCCC2C)c2ccccc2c1=O

CC(C)Cn1cc(NC(=O)NCCN2CCOCC2)c2ccccc2c1=O

MAT-POS-2492181e-11
Duplicate of:
MAT-POS-b5746674-109

CC(C)Cn1cc(NC(=O)NCCN2CCOCC2)c2ccccc2c1=O

CCCN(CCC)CCNC(=O)Nc1cn(CC(C)C)c(=O)c2ccccc12

MAT-POS-2492181e-12

CCCN(CCC)CCNC(=O)Nc1cn(CC(C)C)c(=O)c2ccccc12


Design Rationale:

Ed Griffen's choices for quinolone urea follow-ups from the Weizmann HTS hits

Discussion: