Submission Details
Molecule(s):
N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3[C@H](C(=O)Nc3c(C(F)F)ncc4ccccc34)C2)CC1
N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3[C@H](C(=O)Nc3cnc(C(F)F)c4ccccc34)C2)CC1
N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3[C@H](C(=O)Nc3c(F)ncc4ccccc34)C2)CC1
N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3[C@H](C(=O)Nc3cnc(F)c4ccccc34)C2)CC1
Design Rationale:
Might improve T1/2, bioavailability of this compound, which might be an aldehyde oxidase (A.O.) substrate. Products might be less A.O. susceptible.