Submission Details
Molecule(s):
O=C1C2C=CC=CC2[Se]N1c1cccc(O)c1
O=C1C2C=CC=CC2[Se]N1c1ccc(O)cc1
O=C1C2C=CC=CC2[Se]N1c1ccc(O)c(O)c1
O=C1C2C=CC=CC2[Se]N1c1cccc(F)c1
Design Rationale:
The drawn oragnoselenium compound is an analogue of the antioxidant glutathione peroxidase mimetic, ebselen. Ebselen is in clinical trials as a potent catalytic antioxidant. Previously, ebselen is know to inhibit helicase related to hepatitis C virus It is also known capsid inhibitor of HIV replication. Recently, a report appeared in Biorxiv on the descovery of viral inhibitors, which mentions about the target of SARS-CoV-2 that covalently binds to a catalytic dyad in COVID-19 virus Mpro. In this regard, the analogues of ebselen may be effective.