Submission Details

RAL-THA-176e263b
Molecule(s):
CCC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

RAL-THA-176e263b-1

CCC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CCC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2c(F)cc(F)cc21

RAL-THA-176e263b-2

CCC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2c(F)cc(F)cc21

3-aminopyridine-like Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2c(F)cc(F)cc21

RAL-THA-176e263b-3

CC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2c(F)cc(F)cc21

3-aminopyridine-like Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

RAL-THA-176e263b-4

CC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
Design Rationale:

Methoxy S1 group is (or is likely) to be susceptible to elimination - aromatization in the context of the 1,2,3,4‐tetrahydroisoquinolin‐1‐one template. Examine small alkyl as an alternative: is ethyl a suitable isostere for methoxy?

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners, LLC - Wed, 02 Jun 2021 20:35:16 +0000