Submission Details

EDJ-MED-15e90dfc
Molecule(s):
O=C(Nc1cncc2ccccc12)C1(CNCc2ccn[nH]2)CCOc2ccc(Cl)cc21

EDJ-MED-15e90dfc-1
Duplicate of:
EDJ-MED-f893e2a1-1

O=C(Nc1cncc2ccccc12)C1(CNCc2ccn[nH]2)CCOc2ccc(Cl)cc21

Duplicate 3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1(CNc2ccn[nH]2)CCOc2ccc(Cl)cc21

EDJ-MED-15e90dfc-2

O=C(Nc1cncc2ccccc12)C1(CNc2ccn[nH]2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
COCCNCC1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

EDJ-MED-15e90dfc-3
Duplicate of:
EDJ-MED-424a8a89-1

COCCNCC1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

Duplicate 3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1(CNCc2ccccn2)CCOc2ccc(Cl)cc21

EDJ-MED-15e90dfc-4

O=C(Nc1cncc2ccccc12)C1(CNCc2ccccn2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1(CNc2ccccn2)CCOc2ccc(Cl)cc21

EDJ-MED-15e90dfc-5

O=C(Nc1cncc2ccccc12)C1(CNc2ccccn2)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C1CCC(CNCC2(C(=O)Nc3cncc4ccccc34)CCOc3ccc(Cl)cc32)N1

EDJ-MED-15e90dfc-6

O=C1CCC(CNCC2(C(=O)Nc3cncc4ccccc34)CCOc3ccc(Cl)cc32)N1

3-aminopyridine-like Check Availability on Manifold View
CS(=O)(=O)CCNCC1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

EDJ-MED-15e90dfc-7

CS(=O)(=O)CCNCC1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Design based on high FEP scoring compound VLA-UCB-34F3ED0C-16 and Peter Kenny design PET-UNK-4880b143-1. Lower priority as EDG-MED-971238d3-5 is less potent than MAT-POS-3b97339c-2 however reductive amination chemistry easier with this linker. .Some variation on chain length to test SAR.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Tue, 23 Feb 2021 21:00:17 +0000