Submission Details

ALE-ALC-159be365

Molecule(s):

COC(=O)c1cccc2c(NC(=O)[C@@H]3CN(S(=O)(=O)CC4(C#N)CC4)Cc4ccc(Cl)cc43)cncc12

ALE-ALC-159be365-1

COC(=O)c1cccc2c(NC(=O)[C@@H]3CN(S(=O)(=O)CC4(C#N)CC4)Cc4ccc(Cl)cc43)cncc12

Check Availability on Manifold View

Design Rationale:

the presence of a nitrogen near where the carboxyl group is when in side protease

Inspired By:

N#CC1(CS(=O)(=O)N2Cc3ccc(Cl)cc3[C@H](C(=O)Nc3cncc4c(C(=O)O)cccc34)C2)CC1

ALE-ALC-b4762a05-1

Discussion:

Contributor: alex, alchemical biological research - Sun, 01 Jan 2023 11:02:24 +0000