O=C1N(c2cncc3ccccc23)CC[C@@]12CCOc1ccc(Cl)cc12
Clc1ccc2c(c1)[C@]1(CCO2)CCN(c2cncc3ccccc23)C1
O=C1C[C@]2(CCOc3ccc(Cl)cc32)CN1c1cncc2ccccc12
Building on the potency of VLA-UCB-50c39ae8-2 (single enantiomer prepare the lactams by imide reduction and the spiropyrollidine which should maintain the required shape but with lower desolvation, albeit loosing the hydrogen bond to Glu 166.