Submission Details
Molecule(s):
CNC(=O)CCc1nn(C)c(-c2ccc(C(=O)NNC(=O)CCl)s2)c1Cl
Design Rationale:
Hybrid of covalent fragmnet x0708 and non-covalent x0104. literature supported synthesis (also for analogues) from readily available reagents in 4 steps.
Other Notes:
From CAS1517432-28-8n(suppliers FCH and others) : reaction (1): reductive amination with CAS868-83-7 (available from nmany, including ABCR, AK scientific). reference Acta chimica sinica 2015,73.1311-1314. reaction (2): regioselective bromination (reference Orglett 2018,20,3114. recation (3): heck reaction (many references) with reagent CAS1187-59-3. (options are available for analogues).