Submission Details

MAT-POS-136e7878
Molecule(s):
Cc1ccncc1NC(=O)N(CCC1CCCCC1)c1cccc(Cl)c1

MAT-POS-136e7878-1

Cc1ccncc1NC(=O)N(CCC1CCCCC1)c1cccc(Cl)c1

3-aminopyridine-like Check Availability on Manifold View
COc1cc(Cl)cc(N(CCC2CCCCC2)C(=O)Nc2cnccc2C)c1

MAT-POS-136e7878-2

COc1cc(Cl)cc(N(CCC2CCCCC2)C(=O)Nc2cnccc2C)c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

adding methyl on pyridine to pick up the extra potency we observe from this addition with TRY-UNI-714a760b-6. Also adding methoxy to match the potent chlorobenzene in AGN-NEW-891393a6-1

Inspired By:
Discussion:

Contributor: Matt Robinson, PostEra - Thu, 16 Jul 2020 04:16:06 +0000