Submission Details

Molecule(s):
COc1cc(C2CC(c3cccs3)=NN2C(=O)COC(C)=O)ccc1OC(F)F

NIM-UNI-13494739-1

COc1cc(C2CC(c3cccs3)=NN2C(=O)COC(C)=O)ccc1OC(F)F

Cc1ccc(C2=NN(C(=O)CCl)C(c3ccco3)C2)cc1

NIM-UNI-13494739-2

Cc1ccc(C2=NN(C(=O)CCl)C(c3ccco3)C2)cc1

COc1ccc(C2CC(c3cccs3)=NN2C(=O)COC(C)=O)cc1OC

NIM-UNI-13494739-3

COc1ccc(C2CC(c3cccs3)=NN2C(=O)COC(C)=O)cc1OC

COc1cc(C2CC(c3cccs3)=NN2C(=O)CCl)ccc1OC(F)F

NIM-UNI-13494739-4

COc1cc(C2CC(c3cccs3)=NN2C(=O)CCl)ccc1OC(F)F

O=C(CCl)N1N=C(c2ccco2)CC1c1cccc(Cl)c1

NIM-UNI-13494739-5

O=C(CCl)N1N=C(c2ccco2)CC1c1cccc(Cl)c1

O=C(CCl)N1N=C(c2ccco2)CC1c1cccs1

NIM-UNI-13494739-6

O=C(CCl)N1N=C(c2ccco2)CC1c1cccs1

COc1ccc(C2CC(c3ccc4ccccc4c3)=NN2C(=O)CCl)cc1

NIM-UNI-13494739-7

COc1ccc(C2CC(c3ccc4ccccc4c3)=NN2C(=O)CCl)cc1

COc1ccc(C2CC(c3ccccc3)=NN2C(=O)CCl)cc1

NIM-UNI-13494739-8

COc1ccc(C2CC(c3ccccc3)=NN2C(=O)CCl)cc1

O=C(CCl)N1N=C(c2cccs2)CC1c1cccs1

NIM-UNI-13494739-9

O=C(CCl)N1N=C(c2cccs2)CC1c1cccs1

O=C(CCl)N1N=C(c2cccs2)CC1c1ccco1

NIM-UNI-13494739-10

O=C(CCl)N1N=C(c2cccs2)CC1c1ccco1

COc1ccc(C2=NN(C(=O)CCl)C(c3ccco3)C2)cc1

NIM-UNI-13494739-11

COc1ccc(C2=NN(C(=O)CCl)C(c3ccco3)C2)cc1

O=C(CCl)N1N=C(c2ccc(Cl)cc2)CC1c1ccco1

NIM-UNI-13494739-12

O=C(CCl)N1N=C(c2ccc(Cl)cc2)CC1c1ccco1


Design Rationale:

Based on IC50 value of MAT-POS-916a2c5a-1, I submitted this structure to REAL space navigator and these were the alphachloropyrazines in REAL space.

Inspired By:
Discussion: