O=C(Nc1onc2ccccc12)C1CCOc2ccc(Cl)cc21
O=C(NCn1ccccc1=O)C1CCOc2ccc(Cl)cc21
O=c1ccccn1Cc1nnnn1C1CCOc2ccc(Cl)cc21
O=c1ccccn1Cc1nnnn1Cc1cccc(Cl)c1
O=c1ccccn1Cc1snnc1C1CCOc2ccc(Cl)cc21
O=c1ccccn1Cc1snnc1Cc1cccc(Cl)c1
O=C(Nc1snc2ccccc12)C1CCOc2ccc(Cl)cc21
Isoquinoline replacements: recycling two previous ideas (benzoxazole/benzthiazole) that have not been tested yet. Adding a more adventurous third option with 2-pyridone. Although the "geminal" linking is not ideal for stability, it might be easier to make than the tetrazole/thiadiazole analogs.