Submission Details
Molecule(s):
O=C(CCl)c1ccc(Br)c2[nH]c(=O)n(-c3cccnc3)c12
O=C(CCl)c1ccc(Cc2ccc(Br)cc2)c2[nH]c(=O)n(-c3cccnc3)c12
N#Cc1ccc(C(=O)CCl)c2c1[nH]c(=O)n2-c1cccnc1
O=C(CCl)c1cccc2c1n(-c1cccnc1)c(=O)n2-c1ccccc1
O=C(CCl)CC1CNC(=O)N1c1cccnc1
Design Rationale:
New scaffold based on overlaying inhibitors. Also considered ease of synthesis, and handles for elaborating using cross-coupling.
Other Notes:
Resubmitting compounds with alpha chloro so they are covalent inhibitors.