O=c1cc(C2CCCC2)oc2ccc(Br)cc12
COc1ccc2oc(C3CCCC3)cc(=O)c2c1
O=c1cc(C2CCCCC2)oc2ccc(N3CCOCC3)cc12
CN1CCN(c2ccc3oc(C4CCCCC4)cc(=O)c3c2)CC1
O=c1cc(C2CCCCC2)oc2ccc(-c3ccccc3)cc12
O=c1cc(C2CCCCC2)oc2ccccc12
Chromones have been identified as privileged scaffolds in drug discovery and reported as antivirals in the treatment of HIV (1) Para substitution on the B ring has been reported as required to promote antiplasmodial activity and increase HIV-2 potency (2) Naturally occurring medicinal plant containing chromones have been shown to inhibit SARS-CoV-2 3CLpro activity and hence virus replication in computational screening (3) 1. Keri, R. S.; Budagumpi, S.; Pai, R. K.; Balakrishna, R. G., Chromones as a privileged scaffold in drug discovery: A review. European Journal of Medicinal Chemistry, 2014, 78, 340. 2. Casano, G.; Dumètre, A.; Pannecouque, C.; Hutter, S.; Azas, N.; Robin, M., Anti-HIV and antiplasmodial activity of original flavonoid derivatives. Bioorganic & Medicinal Chemistry, 2010, 18, 6012. 3. ul Qamar, M. T.; Alqahtani, S. M.; Alamri, M. A.; Chen, L.-L., Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants†. Journal of Pharmaceutical Analysis, 2020.
Most of these compounds readily accessible and the others can be simply remade. The synthesis of these compounds is simple and can be easily reproduced to produce a range of analogues (4, 5) 4. Abdel Ghani, S. B.; Mugisha, P. J.; Wilcox, J. C.; Gado, E. A. M.; Medu, E. O.; Lamb, A. J.; Brown, R. C. D., Convenient One-Pot Synthesis of Chromone Derivatives and Their Antifungal and Antibacterial Evaluation. Synthetic Communications, 2013, 43, 1549. 5. Abdel Ghani, S. B.; Weaver, L.; Zidan, Z. H.; Ali, H. M.; Keevil, C. W.; Brown, R. C. D., Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives. Bioorganic & Medicinal Chemistry Letters, 2008, 18, 518.