Submission Details

EDJ-MED-0d144977
Molecule(s):
Cc1nc(CN2CC3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc3C2=O)c[nH]1

EDJ-MED-0d144977-1

Cc1nc(CN2CC3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc3C2=O)c[nH]1

3-aminopyridine-like Check Availability on Manifold View
Cn1cncc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

EDJ-MED-0d144977-2

Cn1cncc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

3-aminopyridine-like Check Availability on Manifold View
Cn1nccc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

EDJ-MED-0d144977-3
Duplicate of:
EDJ-MED-cc48ee33-7

Cn1nccc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
Cn1ncnc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

EDJ-MED-0d144977-4

Cn1ncnc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

3-aminopyridine-like Ordered Check Availability on Manifold View
Cn1ccnc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

EDJ-MED-0d144977-5

Cn1ccnc1CN1CC2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc2C1=O

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Analogues of EDJ-MED-41558c53-6 with potential of better potency and metabolic stability.

Discussion:

Contributor: Ed J Griffen, MedChemica Consultancy Ltd - Tue, 18 Jan 2022 14:30:31 +0000