Submission Details
Molecule(s):
CS(=O)(=O)NCCOc1cc2ccncc2cc1Oc1ccccc1F
CNCc1cc(-c2ccccc2F)n(C(C)NC(=O)CCCNC(C)=O)c1
CNCc1cc(-c2ccccc2F)n(C(C(=O)NC)c2cccnc2)c1
CNCc1cc(-c2ccccc2F)n(C(CCNC(=O)OC)c2cccnc2)c1
CNCc1cc(-c2ccccc2F)n(C(CC(=O)OCCOC(C)=O)c2cccnc2)c1
CNCc1cc(-c2ccccc2F)n(Cn2ccnc2)c1
CNCc1cc(-c2ccccc2F)n(C(C)NC)c1
CNCc1cc(-c2ccccc2F)n(Cc2ccsc2)c1
CNCc1cc(-c2ccccc2F)n(CC(N)c2ncc(C)c(C=O)n2)c1
CNCc1cc(-c2ccccc2F)n(CC/C=C/COC=O)c1
CNCc1cc(-c2ccccc2F)n(CNC)c1
CNCc1cc(-c2ccccc2F)n(C(O)c2ccccc2)c1
CNCc1cc(-c2ccccc2F)n(Cc2ccccc2)c1
CNCc1cc(-c2ccccc2F)n(C(C)c2ccccc2)c1
CNCc1cc(-c2ccccc2F)n(C2CCN(C(N)=O)C2)c1
CNCc1cc(-c2ccccc2F)n(C(c2ccccc2)c2c[nH]nn2)c1
CNCc1cc(-c2ccccc2F)n(COC2CCC(OC=O)CC2)c1
CNCc1cc(-c2ccccc2F)n(C(=O)NC2CCC(C(=O)O)=CC2OC)c1
CC/C=C\Cn1cc(CNC)cc1-c1ccccc1F
CNCc1cc(-c2ccccc2F)n(CCC2CC2C)c1
CCC(=O)OC(C)n1cc(CNC)cc1-c1ccccc1F
CNCc1cc(-c2ccccc2F)n(CC(C)O)c1
CCCn1cc(CNC)cc1-c1ccccc1F
CNCc1cc(-c2ccccc2F)n(CCCNC(=O)c2ccccc2)c1
CNCc1cc(-c2ccccc2F)n(Cc2ccccc2C)c1
CNCc1cc(-c2ccccc2F)n(Cc2c[nH]c3c(C#N)cnn3c2=O)c1
CNCc1cc(-c2ccccc2F)n(C(=O)CCO)c1
CNCc1cc(-c2ccccc2F)c(S(=O)(=O)c2cccnc2)[nH]1
CNCc1cc(S(=O)(=O)c2cccnc2)c(-c2ccccc2F)n1-c1cc[nH]n1
CNCc1cc(S(=O)(=O)c2cccnc2)c(-c2ccccc2F)n1-c1c(O)cc(C(=O)O)c(O)c1I
CNCc1cc(-c2ccc(-c3ccccc3)cc2C)n(S(=O)(=O)c2cccnc2)c1
CNCc1cc(-c2ccc(-c3ccccc3)nc2)n(S(=O)(=O)c2cccnc2)c1
CNCc1cc(-c2ccc(-c3ccc(-n4cnn(CS(C)(=O)=O)c4=O)cc3)cc2F)n(S(=O)(=O)c2cccnc2)c1
CNCc1cc(-c2ccc(CCNC(=O)CNC(=O)c3cnc(C)s3)cc2F)n(S(=O)(=O)c2cccnc2)c1
Design Rationale:
+ vonoprazan, SeeSAR Inspirator