Submission Details
Molecule(s):
O=C(Cc1cccc(Cl)c1)N1CCCOC2C=CC=C3C=NC=C1C32
O=C(Cc1cccc(Cl)c1)N1CCOC2C=CC=C3C=NC=C1C32
O=C(Cc1cccc(Cl)c1)N1CCCCC2C=CC=C3C=NC=C1C32
O=C(Cc1cccc(Cl)c1)N1CCCC2C=CC=C3C=NC=C1C32
Design Rationale:
Another attempt at bending amide out of plane of isoquinoline. If there's an easy way to introduce allyl or vinyl ipso- relative to amine in isoquinoline, then compounds 3 and 4 could be made by N-allylation, followed by RCM and hydrogenation