Submission Details

RAL-THA-065e0743
Molecule(s):
CNC(=O)Cn1cc(CC(=O)Nc2cncc3ccccc23)ccc1=O

RAL-THA-065e0743-1

CNC(=O)Cn1cc(CC(=O)Nc2cncc3ccccc23)ccc1=O

3-aminopyridine-like Check Availability on Manifold View
Cc1ncc2ccccc2c1NC(=O)Cc1cc(Cl)cc(OC2CC(=O)N2)c1

RAL-THA-065e0743-2

Cc1ncc2ccccc2c1NC(=O)Cc1cc(Cl)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Follow up of ALP-POS-3b848b35-2. Add Me group ortho to quinoline N to block CYP inhibition. Beta-lactam replacement

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Tue, 29 Sep 2020 21:13:09 +0000