Submission Details

RAL-THA-05e671eb
Molecule(s):
O=C(Nc1cncc2ccccc12)C1CCOc2ccccc21

RAL-THA-05e671eb-1

O=C(Nc1cncc2ccccc12)C1CCOc2ccccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)c(Cl)cc21

RAL-THA-05e671eb-2
Duplicate of:
ALP-POS-869ac754-1

O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)c(Cl)cc21

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)ccc21

RAL-THA-05e671eb-3

O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)ccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2ccc(F)cc21

RAL-THA-05e671eb-4

O=C(Nc1cncc2ccccc12)C1CCOc2ccc(F)cc21

3-aminopyridine-like Check Availability on Manifold View
Cc1ccc2c(c1)C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-5

Cc1ccc2c(c1)C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2ccc(C(F)(F)F)cc21

RAL-THA-05e671eb-6

O=C(Nc1cncc2ccccc12)C1CCOc2ccc(C(F)(F)F)cc21

3-aminopyridine-like Check Availability on Manifold View
N#Cc1ccc2c(c1)C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-7
Duplicate of:
DAR-DIA-6a508060-3

N#Cc1ccc2c(c1)C(C(=O)Nc1cncc3ccccc13)CCO2

Duplicate 3-aminopyridine-like Check Availability on Manifold View
COc1ccc2c(c1)C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-8

COc1ccc2c(c1)C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
Cc1cc2c(cc1Cl)C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-9

Cc1cc2c(cc1Cl)C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cc(F)c(Cl)cc21

RAL-THA-05e671eb-10

O=C(Nc1cncc2ccccc12)C1CCOc2cc(F)c(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)c(F)cc21

RAL-THA-05e671eb-11
Duplicate of:
ALP-UNI-3735e77e-3

O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)c(F)cc21

Duplicate 3-aminopyridine-like Check Availability on Manifold View
Cc1ccc2c(c1)OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-12

Cc1ccc2c(c1)OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cc(F)ccc21

RAL-THA-05e671eb-13

O=C(Nc1cncc2ccccc12)C1CCOc2cc(F)ccc21

3-aminopyridine-like Check Availability on Manifold View
COc1ccc2c(c1)OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-14

COc1ccc2c(c1)OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
N#Cc1ccc2c(c1)OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-15

N#Cc1ccc2c(c1)OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2c(Cl)cc(Cl)cc21

RAL-THA-05e671eb-16
Duplicate of:
ALP-UNI-3735e77e-2

O=C(Nc1cncc2ccccc12)C1CCOc2c(Cl)cc(Cl)cc21

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2c(F)cc(Cl)cc21

RAL-THA-05e671eb-17

O=C(Nc1cncc2ccccc12)C1CCOc2c(F)cc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Cc1cc(Cl)cc2c1OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-18

Cc1cc(Cl)cc2c1OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
COc1cc(Cl)cc2c1OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-19
Duplicate of:
DAR-DIA-6a508060-4

COc1cc(Cl)cc2c1OCCC2C(=O)Nc1cncc2ccccc12

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
N#Cc1cc(Cl)cc2c1OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-20

N#Cc1cc(Cl)cc2c1OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2c(Cl)cccc21

RAL-THA-05e671eb-21

O=C(Nc1cncc2ccccc12)C1CCOc2c(Cl)cccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2c(F)cccc21

RAL-THA-05e671eb-22

O=C(Nc1cncc2ccccc12)C1CCOc2c(F)cccc21

3-aminopyridine-like Check Availability on Manifold View
COc1cccc2c1OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-23

COc1cccc2c1OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
N#Cc1cccc2c1OCCC2C(=O)Nc1cncc2ccccc12

RAL-THA-05e671eb-24

N#Cc1cccc2c1OCCC2C(=O)Nc1cncc2ccccc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2ncc(Cl)cc21

RAL-THA-05e671eb-25

O=C(Nc1cncc2ccccc12)C1CCOc2ncc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)cnc21

RAL-THA-05e671eb-26

O=C(Nc1cncc2ccccc12)C1CCOc2cc(Cl)cnc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2ccc(Cl)c(Cl)c21

RAL-THA-05e671eb-27

O=C(Nc1cncc2ccccc12)C1CCOc2ccc(Cl)c(Cl)c21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2ccc(Cl)c(F)c21

RAL-THA-05e671eb-28

O=C(Nc1cncc2ccccc12)C1CCOc2ccc(Cl)c(F)c21

3-aminopyridine-like Check Availability on Manifold View
Cc1c(Cl)ccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-29

Cc1c(Cl)ccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
COc1c(Cl)ccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-30

COc1c(Cl)ccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
N#Cc1c(Cl)ccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-31

N#Cc1c(Cl)ccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cccc(Cl)c21

RAL-THA-05e671eb-32

O=C(Nc1cncc2ccccc12)C1CCOc2cccc(Cl)c21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncc2ccccc12)C1CCOc2cccc(F)c21

RAL-THA-05e671eb-33

O=C(Nc1cncc2ccccc12)C1CCOc2cccc(F)c21

3-aminopyridine-like Check Availability on Manifold View
Cc1cccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-34

Cc1cccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
COc1cccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-35

COc1cccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
N#Cc1cccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

RAL-THA-05e671eb-36

N#Cc1cccc2c1C(C(=O)Nc1cncc3ccccc13)CCO2

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Systematic SAR exploration around VLA-UCB-1dbca3b4-15 per Design Team discussion on 16 Dec 2020

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Thu, 17 Dec 2020 20:18:32 +0000