Submission Details

Molecule(s):
O=C(Nc1nncn1C1CC1)C1CCOc2ccc(Cl)c(F)c21

JOH-UNI-04a01eac-1

O=C(Nc1nncn1C1CC1)C1CCOc2ccc(Cl)c(F)c21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncn1C1CC1)C1(F)CCOc2ccc(Cl)cc21

JOH-UNI-04a01eac-2

O=C(Nc1cncn1C1CC1)C1(F)CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cncn1C1CC1)C1CCOc2ccc(Cl)c(F)c21

JOH-UNI-04a01eac-3

O=C(Nc1cncn1C1CC1)C1CCOc2ccc(Cl)c(F)c21

3-aminopyridine-like Check Availability on Manifold View
Cc1ncc(NC(=O)C2(F)CCOc3ccc(Cl)cc32)n1C1CC1

JOH-UNI-04a01eac-4

Cc1ncc(NC(=O)C2(F)CCOc3ccc(Cl)cc32)n1C1CC1

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

potential masked H-bond may improve permeation, reduce efflux.

Discussion: