Submission Details
Molecule(s):
O=C(c1ccccc1O)N1CCCCC1
O=C(Nc1ccccc1)c1ccccc1O
NC(=O)C1CCN(C(=O)c2ccccc2O)CC1
O=C(O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
Design Rationale:
The design was done using the fragments to create a "model fragment" which was used to search for drugs with similar fragments. The idea is that this will inform rational linking of the fragments. A prominent feature of the molecules is the salicyliamide moiety. This has been reported to poses antiviral activities and with anticlotting properties. It was reported recently that blood clotting contribute to respiratory failure in Covid-19 patients. Finally, the molecules are stable and synthetic chemistry friendly.
Other Notes:
Used fragments PCM-0102389, PCM-0102219. Can't find the X-codes for all fragments.