Submission Details

EDJ-MED-015fb6b4
Molecule(s):
CNC(=O)CN1CC(OC)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

EDJ-MED-015fb6b4-1

CNC(=O)CN1CC(OC)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

CNC(=O)CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

EDJ-MED-015fb6b4-2

CNC(=O)CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

CNC(=O)CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)c(F)cc2C1=O

EDJ-MED-015fb6b4-3

CNC(=O)CN1CC(C(=O)Nc2cncc3ccccc23)c2cc(Cl)c(F)cc2C1=O

Design Rationale:

Combine potency of MAT-POS-4223bc15-23 with the possibility of removing the benzylic metabolic soft spot. In Quaternary-H, Ome forms and the S2 ring Cl and Cl, F rings.

Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Mon, 10 May 2021 11:18:00 +0000