Submission Details

VLA-UNK-3bd6fc51
Molecule(s):
O=C1N(c2cncc3ccccc23)CCC12CN(CC(F)(F)Cl)Cc1ccc(Cl)cc12

VLA-UNK-3bd6fc51-1

O=C1N(c2cncc3ccccc23)CCC12CN(CC(F)(F)Cl)Cc1ccc(Cl)cc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Inspired by the post below suggesting CF2Cl as an isostere to sulphonamide: https://www.linkedin.com/pulse/aliphatic-chlorides-drug-design-gilles-ouvry/

Other Notes:

Building block available at Enamine for a single step nucleophilic substitution on secondary amine building block: https://www.enaminestore.com/catalog/EN300-26666824

Inspired By:
Discussion:

Contributor: Vladas Oleinikovas - Sat, 22 Jan 2022 09:54:24 +0000