Submission Details

Molecule(s):
N#Cc1cc(NC(=O)Cc2cncnc2)cc(OC2CC(=O)N2)c1

TRY-UNI-bbd40bb4-1

N#Cc1cc(NC(=O)Cc2cncnc2)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1CC(=O)Nc1cc(C#N)cc(OC2CC(=O)N2)c1

TRY-UNI-bbd40bb4-2

Cc1ccncc1CC(=O)Nc1cc(C#N)cc(OC2CC(=O)N2)c1

3-aminopyridine-like Check Availability on Manifold View
O=C1CC(OCc2ccc(NC(=O)Nc3cccnc3)s2)N1

TRY-UNI-bbd40bb4-3

O=C1CC(OCc2ccc(NC(=O)Nc3cccnc3)s2)N1

3-aminopyridine-like Check Availability on Manifold View
O=C1CC(Oc2ccc(NC(=O)Nc3cccnc3)s2)N1

TRY-UNI-bbd40bb4-4

O=C1CC(Oc2ccc(NC(=O)Nc3cccnc3)s2)N1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Nc1ccc(COC2CC(=O)N2)s1

TRY-UNI-bbd40bb4-5

Cc1ccncc1NC(=O)Nc1ccc(COC2CC(=O)N2)s1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Nc1ccc(OC2CC(=O)N2)s1

TRY-UNI-bbd40bb4-6

Cc1ccncc1NC(=O)Nc1ccc(OC2CC(=O)N2)s1

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

The design of the molecules was done by superimposing the different fragments from the crystal structures (by eye). The reactions should be fairly easy urea formation or amide coupling all from readily available starting materials. Fragments used for the conception of the ideas are the following x2562, x2608

Inspired By:
Discussion: