Submission Details

SEA-TRI-8252c13b
Molecule(s):
O=C(CCl)N1CCN(Cc2ccc(Cl)s2)C[C@@H]1Cc1ccc(O)cc1

SEA-TRI-8252c13b-1

O=C(CCl)N1CCN(Cc2ccc(Cl)s2)C[C@@H]1Cc1ccc(O)cc1

piperazine-chloroacetamide Check Availability on Manifold View
Design Rationale:

Merging non covalent and covalent hit Targetting DMSO/water pocket seen frequently in crystal structures. Valuable to consider alternative cysteine reactive groups e.g. Micheal acceptors.

Other Notes:

SMcK-020

Inspired By:
Discussion:

Contributor: Sean McKenna, Trinity College Dublin - Thu, 02 Apr 2020 10:21:38 +0000