Submission Details

SEA-TRI-5a552082
Molecule(s):
C=CS(=O)(=O)CN(C(=O)Nc1cccc(Cl)c1)c1cncnc1

SEA-TRI-5a552082-1

C=CS(=O)(=O)CN(C(=O)Nc1cccc(Cl)c1)c1cncnc1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Non covalent -> covalent binder. Pyridyl -> pyrimidyl to account for CyP450s Alternative michael acceptor (cysteine selective)

Other Notes:

SMcK-005

Inspired By:
Discussion:

Contributor: Sean McKenna, Trinity College Dublin - Thu, 02 Apr 2020 08:10:16 +0000