Submission Details

RAL-THA-b9d6aec1
Molecule(s):
CN(C)S(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1

RAL-THA-b9d6aec1-1

CN(C)S(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
CNS(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1

RAL-THA-b9d6aec1-2

CNS(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
NS(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1

RAL-THA-b9d6aec1-3

NS(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Sulfonamide as alternative to sulfone substituent on the IQ ring. Less electron withdrawing than sulfone (?), and therefore less reduction of the basicity of the IQ nitrogen.

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Thu, 22 Apr 2021 13:47:14 +0000