Submission Details

RAL-THA-b00e3cbf
Molecule(s):
N#Cc1ncc(NC(=O)C2CCOc3ccc(Cl)cc32)c2ccccc12

RAL-THA-b00e3cbf-1

N#Cc1ncc(NC(=O)C2CCOc3ccc(Cl)cc32)c2ccccc12

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Reduce potential for CYP inhibition; reduce clearance. Prepare via SnAR on 4‐bromoisoquinoline‐1‐carbonitrile, which in turn can be made from 4-bromoisoquinoline. See US 20040077605

Inspired By:
Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Tue, 30 Mar 2021 13:25:34 +0000