Submission Details

RAL-THA-6b94ceba
Molecule(s):
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ncc[nH]2)c1

RAL-THA-6b94ceba-1

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ncc[nH]2)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ncn[nH]2)c1

RAL-THA-6b94ceba-2

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ncn[nH]2)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2cnc[nH]2)c1

RAL-THA-6b94ceba-3

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2cnc[nH]2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ccn[nH]2)c1

RAL-THA-6b94ceba-4

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ccn[nH]2)c1

3-aminopyridine-like Check Availability on Manifold View
CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-5

CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(N)=O)c1

RAL-THA-6b94ceba-6

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(N)=O)c1

3-aminopyridine-like Ordered Check Availability on Manifold View
CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-7

CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-8

COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ncc[nH]2)c1

RAL-THA-6b94ceba-9

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ncc[nH]2)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2nnc[nH]2)c1

RAL-THA-6b94ceba-10

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2nnc[nH]2)c1

3-aminopyridine-like Ordered Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2cnc[nH]2)c1

RAL-THA-6b94ceba-11

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2cnc[nH]2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

RAL-THA-6b94ceba-12

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(S(N)(=O)=O)c1

RAL-THA-6b94ceba-13

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(S(N)(=O)=O)c1

3-aminopyridine-like Assayed Check Availability on Manifold View
CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-14

CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

3-aminopyridine-like Ordered Check Availability on Manifold View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CS(N)(=O)=O)c1

RAL-THA-6b94ceba-15

Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CS(N)(=O)=O)c1

3-aminopyridine-like Check Availability on Manifold View
CNS(=O)(=O)Cc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-16

CNS(=O)(=O)Cc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Follow up of beta lactam TRY-UNI-2eddb1ff-7: beta-lactam replacements, generally retaining the H-bond donor proximal to the phenyl ring. Relative synthetic ease taken into account.

Discussion:

Contributor: Ralph Robinson, Thames Pharma Partners - Thu, 23 Jul 2020 21:25:12 +0000